19 questions · 14 sources · 0 syntheses
Neurodegenerative Disease
Diseases involving progressive loss of neurons, such as Alzheimer's.
Source-derived questions
Questions extracted from the papers in this topic, excluding the curated questions above.
- How are defects in ubiquitin pathways connected to diseases like Parkinson's and cancer?
- How did the audience react when Alzheimer first presented his findings to fellow psychiatrists?
- How did the prion mechanism later connect to research on Alzheimer's and Parkinson's disease?
- How does L-DOPA therapy restore movement to Parkinson's patients?
- How has condensate malfunction been linked to neurodegenerative diseases like ALS?
- How long did Stephen Hawking live after his motor neurone disease diagnosis, compared to the original prognosis?
- What did Arvid Carlsson prove about dopamine that overturned earlier assumptions?
- What happened to patients with encephalitis lethargica when treated with L-DOPA?
- What is the C9orf72 repeat expansion, and why does it link ALS and frontotemporal dementia?
- What symptoms did Auguste Deter show that puzzled her physician?
- Which diseases are linked to disruption of the ubiquitin-proteasome pathway?
- Which human diseases are linked to disruptions in cellular vesicle trafficking?
Show 7 more questions
- Who named the disease after Alzheimer, and when?
- Why do neurodegenerative diseases like Parkinson's and ALS involve the same pathway Mori and Walter mapped?
- Why does damage to the hippocampus so severely impair a person's ability to navigate?
- Why is autophagy implicated in diseases like Parkinson's, Alzheimer's, and type 2 diabetes?
- Why is loss of navigational ability often one of the earliest symptoms of Alzheimer's disease?
- Why is protein misfolding connected to diseases like Alzheimer's and Parkinson's?
- Why were ALS and frontotemporal dementia previously considered unrelated diseases before this discovery?
Sources
- Alois Alzheimer's first description of Alzheimer's disease
- Breakthrough Prize in Life Sciences 2026
- Death of Oliver Sacks
- Death of Stephen Hawking
- Lasker Award (Basic Medical Research)
- Lasker Award (Basic Medical Research)
- Lasker Award (Basic Medical Research)
- Lasker Award (Basic Medical Research)
- Lasker Award (Basic Medical Research)
- Nobel Prize in Chemistry
- Nobel Prize in Physiology or Medicine
- Nobel Prize in Physiology or Medicine