34 questions · 18 sources · 0 syntheses
Developmental Biology
How organisms grow and develop from a single cell.
Source-derived questions
Questions extracted from the papers in this topic, excluding the curated questions above.
- How can a graph-based model of auxin transport, with non-polar (undirected) membrane edges, still produce directional vein patterns in a leaf?
- How did scientists study nerve fibre development before Harrison's technique existed?
- How do changes in the diffusion rates of activator and substrate molecules alter the number and size of simulated vascular bundles?
- How does coupling a Turing-like reaction-diffusion instability with longitudinal efflux of a regulatory molecule generate three-dimensional vascular bundle patterns in plant stems?
- How does intoxicated C. elegans movement differ measurably from that of sober worms?
- How does modeling cells as graph nodes and intercellular membranes as unoriented edges allow branching vein patterns to emerge from a single auxin source-sink pair?
- How does modeling developing tissue as a porous medium change predictions of morphogen gradient shape compared to simplified diffusion models?
- How long did it take scientists to understand the molecular mechanism behind Spemann's organiser?
- How many protein-coding genes did the C. elegans genome turn out to contain, and why did that number surprise researchers?
- In what sense does the steady-state behavior of this discrete auxin transport model satisfy Murray's Law for branching transport networks?
- What are homeotic genes, and what happens when they mutate?
- What did Rita Levi-Montalcini observe when a mouse tumour was implanted near a chick embryo's nervous system?
Show 22 more questions
- What did Spemann's experiments reveal about how cells communicate during development?
- What did having the complete cell lineage of C. elegans mapped since the 1980s make possible once its genome was sequenced?
- What did the study find about the direction hair whorls spiral in the northern versus southern hemisphere?
- What happened when Spemann transplanted tissue from the dorsal lip of the blastopore into another embryo?
- What happens to a child's visual system if input is blocked during the critical developmental window?
- What is imprinting, and what did Konrad Lorenz's work reveal about it?
- What is lin-4, and how did Victor Ambros discover it was controlling the timing of worm development?
- What is the role of positive feedback between auxin flux and transport capacity in stabilizing vein channels during leaf venation?
- What long-running neuroscience debate did Harrison's real-time observation settle?
- What long-standing assumption about adult cells did Dolly's birth overturn?
- What makes olfactory ensheathing cells unusually capable of supporting nerve regrowth?
- What technique did Heeremans develop to sort intoxicated worms from control worms at scale?
- What was lin-4, and how did Ambros and Ruvkun discover it silences a developmental gene in C. elegans?
- Why are morphogen gradients robust to changes in source and sink rates but highly sensitive to pore connectivity of the extracellular space?
- Why did Spemann call the transplanted tissue an 'organiser'?
- Why did Sydney Brenner choose Caenorhabditis elegans as a model organism for developmental biology?
- Why did genes discovered in fruit flies turn out to matter for understanding vertebrate development?
- Why does C. elegans' simple, well-mapped nervous system make it useful for studying how ethanol affects neurons?
- Why does vascular bundle formation fail below a threshold width of parenchymatous tissue, and what does this imply about the evolutionary loss of vascular features in smaller tissue geometries?
- Why was C. elegans considered an ideal organism for sequencing an entire animal genome?
- Why was C. elegans development such a productive system for discovering fundamental biology?
- Why was the scientific consensus before Gurdon's work that cell differentiation was a one-way process?
Sources
- Auxin transport model for leaf venation
- Morphogen gradients are regulated by porous media characteristics of the developing tissue
- Turing-like mechanism in a stochastic reaction-diffusion model recreates three dimensional vascular patterning of plant stems
- Caenorhabditis elegans genome published — first multicellular organism
- Dolly the cloned sheep announced
- First patient partially recovers from paraplegia using transplanted olfactory cells
- Ig Nobel Prize in Anatomy
- Ig Nobel Prize in Chemistry
- Lasker Award (Basic Medical Research)
- Lasker Award (Basic Medical Research)
- Nobel Prize in Physiology or Medicine
- Nobel Prize in Physiology or Medicine