- How does running Bragg's law in reverse let scientists reconstruct a crystal's internal atomic geometry?
Structural Biology
Determining the atomic structure of biological macromolecules.
- How did solving haemoglobin and myoglobin's structures give rise to structural biology as a discipline?
- How did Aaron Klug combine multiple two-dimensional electron microscope projections into a three-dimensional structure?
- Why was this structure considered the most complex ever determined at the time?
- How did Kurt Wüthrich use nuclear magnetic resonance to determine protein structure in solution?
- How does a potassium channel achieve ten-thousand-to-one selectivity over sodium ions that are barely smaller?
- What role does the selectivity filter's geometry play in how neurons fire?
- What decades of persistence did Ada Yonath's work on bacterial ribosomes require before results came?
- Why was crystallising a receptor in the act of activation considered so difficult?
- How did the AlphaFold protein structure database change the work of structural biologists who couldn't crystallise their proteins?
- How did solving the protein-folding problem change the questions structural biologists ask?