Structural Biology

Source-derived questions

Questions extracted from the papers in this topic, excluding the curated questions above.

• How did Aaron Klug combine multiple two-dimensional electron microscope projections into a three-dimensional structure?
• How did Kurt Wüthrich use nuclear magnetic resonance to determine protein structure in solution?
• How did solving haemoglobin and myoglobin's structures give rise to structural biology as a discipline?
• How did solving the protein-folding problem change the questions structural biologists ask?
• How did the AlphaFold protein structure database change the work of structural biologists who couldn't crystallise their proteins?
• How does a potassium channel achieve ten-thousand-to-one selectivity over sodium ions that are barely smaller?
• How does running Bragg's law in reverse let scientists reconstruct a crystal's internal atomic geometry?
• What decades of persistence did Ada Yonath's work on bacterial ribosomes require before results came?
• What role does the selectivity filter's geometry play in how neurons fire?
• Why was crystallising a receptor in the act of activation considered so difficult?
• Why was this structure considered the most complex ever determined at the time?

Sources

• Bragg's law of X-ray diffraction
• Lasker Award (Basic Medical Research)
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry
• Nobel Prize in Chemistry

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