24 questions · 11 almanac · 0 findings

Nuclear Magnetic Resonance

Spectroscopy and imaging based on nuclear spin.

Almanac The Resistance Simply Stopped
  • What modern technologies, like MRI scanners, depend on the superconductivity Onnes first observed in mercury?
Almanac Asking a Nucleus Politely, With Magnets
  • How does the molecular beam magnetic resonance method reveal the magnetic moment of an atomic nucleus?
  • What is the connection between Rabi's resonance technique and the invention of MRI decades later?
Almanac A Fingerprint Made of Radio Waves
  • Why do atomic nuclei absorb and then re-emit radio-frequency energy when placed in a strong magnetic field?
  • Why is hydrogen the most useful nucleus for exploiting nuclear magnetic resonance in the human body?
  • Why was nuclear magnetic resonance renamed 'MRI' for clinical use?
  • How did Bloch and Purcell arrive at the same discovery independently within months of each other?
Almanac Four Hours and Forty-Five Minutes to See a Chest
  • How does nuclear magnetic resonance, originally a chemistry technique, get turned into a way of imaging the inside of a living body?
  • What did Raymond Damadian's INDOMITABLE machine actually produce on 3 July 1977, and how long did the scan take?
  • Why is MRI able to reveal tumours, strokes, and torn ligaments that X-rays and CT scans cannot?
Almanac Pulses, Not Sweeps, Read the Molecule
  • Why were the earliest nuclear magnetic resonance instruments so slow at characterising molecules?
  • How did Ernst's pulse-and-Fourier-transform method speed up NMR measurement?
  • What did two-dimensional NMR make possible for studying protein structure?
Almanac Anatomy, Imaged in the Act
  • How did Weijmar Schultz and colleagues use MRI to study human anatomy during intercourse?
  • What technical challenges did researchers face imaging inside an MRI scanner bore?
  • What did the study confirm or correct about prior anatomical assumptions?
Almanac A Second Kind of Superconductor
  • Why did Abrikosov and Ginzburg's theory of quantised magnetic filaments make high-field superconducting magnets possible?
Almanac A Gradient Field Learns to Draw the Body
  • Why was nuclear magnetic resonance useless for imaging before Paul Lauterbur's 1973 insight?
  • How does varying the magnetic field in a gradient allow different points in a sample to be located precisely?
  • What did Peter Mansfield's echo-planar technique contribute to making MRI clinically useful?
  • How many MRI scans are performed worldwide each year as a result of this work?