Developmental Biology — Graph

How did scientists study nerve fibre development before Harrison's technique existed?
What long-running neuroscience debate did Harrison's real-time observation settle?

What happened when Spemann transplanted tissue from the dorsal lip of the blastopore into another embryo?
Why did Spemann call the transplanted tissue an 'organiser'?
How long did it take scientists to understand the molecular mechanism behind Spemann's organiser?
What did Spemann's experiments reveal about how cells communicate during development?

What happens to a child's visual system if input is blocked during the critical developmental window?

What did Rita Levi-Montalcini observe when a mouse tumour was implanted near a chick embryo's nervous system?

What are homeotic genes, and what happens when they mutate?
Why did genes discovered in fruit flies turn out to matter for understanding vertebrate development?

Why was C. elegans considered an ideal organism for sequencing an entire animal genome?
How many protein-coding genes did the C. elegans genome turn out to contain, and why did that number surprise researchers?
What did having the complete cell lineage of C. elegans mapped since the 1980s make possible once its genome was sequenced?

Why did Sydney Brenner choose Caenorhabditis elegans as a model organism for developmental biology?

What was lin-4, and how did Ambros and Ruvkun discover it silences a developmental gene in C. elegans?

Why was the scientific consensus before Gurdon's work that cell differentiation was a one-way process?

What makes olfactory ensheathing cells unusually capable of supporting nerve regrowth?

How does intoxicated C. elegans movement differ measurably from that of sober worms?
Why does C. elegans' simple, well-mapped nervous system make it useful for studying how ethanol affects neurons?
What technique did Heeremans develop to sort intoxicated worms from control worms at scale?

What did the study find about the direction hair whorls spiral in the northern versus southern hemisphere?

What is lin-4, and how did Victor Ambros discover it was controlling the timing of worm development?
Why was C. elegans development such a productive system for discovering fundamental biology?

How can a graph-based model of auxin transport, with non-polar (undirected) membrane edges, still produce directional vein patterns in a leaf?
What is the role of positive feedback between auxin flux and transport capacity in stabilizing vein channels during leaf venation?
In what sense does the steady-state behavior of this discrete auxin transport model satisfy Murray's Law for branching transport networks?
How does modeling cells as graph nodes and intercellular membranes as unoriented edges allow branching vein patterns to emerge from a single auxin source-sink pair?

How does modeling developing tissue as a porous medium change predictions of morphogen gradient shape compared to simplified diffusion models?
Why are morphogen gradients robust to changes in source and sink rates but highly sensitive to pore connectivity of the extracellular space?

How does coupling a Turing-like reaction-diffusion instability with longitudinal efflux of a regulatory molecule generate three-dimensional vascular bundle patterns in plant stems?
How do changes in the diffusion rates of activator and substrate molecules alter the number and size of simulated vascular bundles?
Why does vascular bundle formation fail below a threshold width of parenchymatous tissue, and what does this imply about the evolutionary loss of vascular features in smaller tissue geometries?