ssci sahil.science
4 questions · 1 almanac · 0 findings

Cryo-Electron Microscopy

Imaging frozen biomolecules to near-atomic resolution.

Connects to Algorithms and Data Structures1 Infectious Disease1 Protein Structure1 Radar Technology1 X-Ray Crystallography1
Almanac Freezing Water Into Glass to See a Protein
  • Why did many proteins, especially membrane proteins, resist the older method of crystallisation for imaging?
  • What does it mean to vitrify water, and why does that matter for imaging a protein with electrons?
  • How did Joachim Frank turn thousands of blurry electron microscope images into one sharp structure?
  • What triggered the 'resolution revolution' in cryo-EM after decades of finicky, indistinct images?