ssci sahil.science
4 questions · 1 almanac · 0 findings

Click and Bioorthogonal Chemistry

Fast, selective reactions for joining molecules, including in living systems.

Connects to Cancer Biology1 Organic Synthesis1 Toxicology1
Almanac Chemistry That Clicks Inside a Cell
  • What made Morten Meldal's copper-catalysed azide-alkyne reaction the ideal realization of Sharpless's click chemistry concept?
  • Why couldn't Meldal's copper-based click reaction be used inside living cells?
  • How did Carolyn Bertozzi engineer a click reaction that works without a metal catalyst?
  • What kinds of biological research became possible once chemists could label molecules on living cells without killing them?