- What did John Sulston's complete cell lineage map reveal about how a multicellular organism develops?
- What is apoptosis, and why is programmed cell death essential to building a healthy body?
- How does the failure of programmed cell death contribute to cancer?
Cell Death and Senescence
Programmed cell death and aging at the cellular level.
- How does the enzyme telomerase counteract the shortening of chromosome ends?
- How is telomerase implicated in both aging and cancer?
- Why does a cell that loses its telomeres stop dividing, while one with runaway telomerase can become cancerous?
- How does the mammalian DNA damage response network decide between repair, pausing division, or cell death?